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  <xsd:element name="NumeratorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_NumeratorAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="DenominatorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_DenominatorAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="fenc_ClassOfWarrantOrRightIssued" substitutionGroup="xbrli:item" />
  <xsd:element name="RecognizedEmployeeExpenseTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_RecognizedEmployeeExpenseTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="ContractorOptionMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_ContractorOptionMember" substitutionGroup="xbrli:item" />
  <xsd:element name="RecognizedEmployeeExpenseLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_RecognizedEmployeeExpenseLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="StockOptionInUsDollarsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_StockOptionInUsDollarsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="StockholdersEquityNoteTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_StockholdersEquityNoteTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="StockOptionActivityAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_StockOptionActivityAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="StockOptionActivityDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_StockOptionActivityDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="StockholdersEquityNoteLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_StockholdersEquityNoteLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="PercentageOfCommonSharesOutstanding" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="fenc_PercentageOfCommonSharesOutstanding" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOrWarrantOrRightOutstandingWeightedAverageRemainingContractualTerms" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="fenc_ClassOrWarrantOrRightOutstandingWeightedAverageRemainingContractualTerms" substitutionGroup="xbrli:item" />
  <xsd:element name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="RobertAndradeMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="fenc_RobertAndradeMember" substitutionGroup="xbrli:item" />
  <xsd:element id="fenc_ExercisePriceOfWarrantsIssued" name="ExercisePriceOfWarrantsIssued" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="fenc_ExpiryDateAxis" name="ExpiryDateAxis" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_ExpiryDateDomain" name="ExpiryDateDomain" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_StockOptionPlanExpenseForAffectedOptions" name="StockOptionPlanExpenseForAffectedOptions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="fenc_EquityFinancingAxis" name="EquityFinancingAxis" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_EquityFinancingDomain" name="EquityFinancingDomain" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_StockIssuedDuringPeriodSharesWarrantsExercised" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="fenc_RoyaltiesPercentage" name="RoyaltiesPercentage" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="fenc_ProcessaPharmaceuticalsIncMember" name="ProcessaPharmaceuticalsIncMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_CollaborativeArrangementSharesToBeIssued" name="CollaborativeArrangementSharesToBeIssued" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="fenc_MilestoneEventAxis" name="MilestoneEventAxis" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_ShareRestrictionExpirationTrancheAxis" name="ShareRestrictionExpirationTrancheAxis" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_ShareRestrictionExpirationTrancheDomain" name="ShareRestrictionExpirationTrancheDomain" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_MilestoneEventDomain" name="MilestoneEventDomain" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_BridgeBankTermLoanMember" name="BridgeBankTermLoanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="fenc_DebtInstrumentNumberOfLoanTranches" name="DebtInstrumentNumberOfLoanTranches" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="fenc_EquityIncentivePlanMember" name="EquityIncentivePlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element name="PremiumOverVolumeWeightedAverageConversionPricePercentage" id="fenc_PremiumOverVolumeWeightedAverageConversionPricePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="VolumeWeightedAveragePriceTerm" id="fenc_VolumeWeightedAveragePriceTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CommitmentFeePercentage" id="fenc_CommitmentFeePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CommonSharesAvailableThroughIssuanceOfWarrants" id="fenc_CommonSharesAvailableThroughIssuanceOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfCommitmentFeesPayableInWarrants" id="fenc_PercentageOfCommitmentFeesPayableInWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfCommitmentFeesPayableInCashOrWarrants" id="fenc_PercentageOfCommitmentFeesPayableInCashOrWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExerciseTermOfWarrants" id="fenc_ExerciseTermOfWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EquityAwardsReleasedFromRestrictionShares" id="fenc_EquityAwardsReleasedFromRestrictionShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PetrichorOpportunitiesFundIMember" id="fenc_PetrichorOpportunitiesFundIMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstClosingNoteMember" id="fenc_FirstClosingNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondClosingNoteMember" id="fenc_SecondClosingNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SubsequentClosingNotesMember" id="fenc_SubsequentClosingNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecuritiesPurchaseAgreementsMember" id="fenc_SecuritiesPurchaseAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BridgeBankMember" id="fenc_BridgeBankMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CashInterestAccrualRateOverPrime" id="fenc_CashInterestAccrualRateOverPrime" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AccrualRatePikInterest" id="fenc_AccrualRatePikInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AccruedPaidInKindInterest" id="fenc_AccruedPaidInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PedmarkMember" id="fenc_PedmarkMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstClosingWarrantMember" id="fenc_FirstClosingWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondClosingWarrantMember" id="fenc_SecondClosingWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DiscountsForPromptPayment" id="fenc_DiscountsForPromptPayment" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfPromptPaymentDiscountsExpectedToPayOut" id="fenc_PercentageOfPromptPaymentDiscountsExpectedToPayOut" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GrossProductRevenue" id="fenc_GrossProductRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ChargebacksDiscountsForPromptPayAndOtherAllowancesMember" id="fenc_ChargebacksDiscountsForPromptPayAndOtherAllowancesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RebatesCustomerFeesCreditsAndCoPayAssistanceMember" id="fenc_RebatesCustomerFeesCreditsAndCoPayAssistanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DiscountsAndAllowancesProvisionForCurrentPeriodSales" id="fenc_DiscountsAndAllowancesProvisionForCurrentPeriodSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DiscountsAndAllowancesPaymentsAndCustomerCreditsIssued" id="fenc_DiscountsAndAllowancesPaymentsAndCustomerCreditsIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ManufacturingCostsCapitalizedToInventory" id="fenc_ManufacturingCostsCapitalizedToInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ManufacturingCostsCapitalizedToInventoryWorkInProcess" id="fenc_ManufacturingCostsCapitalizedToInventoryWorkInProcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ManufacturingCostsCapitalizedToInventoryFinishedGoods" id="fenc_ManufacturingCostsCapitalizedToInventoryFinishedGoods" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ManufacturingCostsCapitalizedToInventoryCostOfProductsSold" id="fenc_ManufacturingCostsCapitalizedToInventoryCostOfProductsSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CanadianFundsTranslatedIntoUsdMember" id="fenc_CanadianFundsTranslatedIntoUsdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OregonHealthAndScienceUniversityAgreementMember" id="fenc_OregonHealthAndScienceUniversityAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LeaseContingenciesMember" id="fenc_LeaseContingenciesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExecutiveSeveranceMember" id="fenc_ExecutiveSeveranceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfSeverancePayments" id="fenc_NumberOfSeverancePayments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TriangleParkNorthCarolinaMember" id="fenc_TriangleParkNorthCarolinaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="HobokenNewJerseyMember" id="fenc_HobokenNewJerseyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OfficeServiceAgreementMember" id="fenc_OfficeServiceAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OperatingLeaseDaysNoticeRequiredToTerminateAgreement" id="fenc_OperatingLeaseDaysNoticeRequiredToTerminateAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OperatingLeaseNumberOfScheduledPaymentIncreases" id="fenc_OperatingLeaseNumberOfScheduledPaymentIncreases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="OperatingLeasePenaltiesAndContingentPaymentsPayable" id="fenc_OperatingLeasePenaltiesAndContingentPaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicensingTermOhsuAgreement" id="fenc_LicensingTermOhsuAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LitigationCiplaAndaMember" id="fenc_LitigationCiplaAndaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DaysFollowingReceiptOfNoticeLetterToFilePatentInfringementSuit" id="fenc_DaysFollowingReceiptOfNoticeLetterToFilePatentInfringementSuit" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DurationOfFdaSAbilityToGiveFinalApprovalToProposedProductsThatReferencePedmark" id="fenc_DurationOfFdaSAbilityToGiveFinalApprovalToProposedProductsThatReferencePedmark" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PedmarkSOrphanDrugExclusivityPeriod" id="fenc_PedmarkSOrphanDrugExclusivityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProvisionForDiscountsAndAllowances" id="fenc_ProvisionForDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DaysNoticeToTerminateOhsuAgreement" id="fenc_DaysNoticeToTerminateOhsuAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DaysNoticeRequiredByFennecToTerminateOhsuAgreement" id="fenc_DaysNoticeRequiredByFennecToTerminateOhsuAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PedmarkSExclusivityPeriodUnderPuma" id="fenc_PedmarkSExclusivityPeriodUnderPuma" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PaymentOfInKindInterest" id="fenc_PaymentOfInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentTotalFuturePaymentsDue" id="fenc_DebtInstrumentTotalFuturePaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CashDenotedInCanadianDollarsMember" id="fenc_CashDenotedInCanadianDollarsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MoneyMarketInvestmentsMember" id="fenc_MoneyMarketInvestmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProductSalesDiscountsAndAllowancesPolicyTextBlock" id="fenc_ProductSalesDiscountsAndAllowancesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LeaseLiabilitiesToBePaidBeforeImputedInterest" id="fenc_LeaseLiabilitiesToBePaidBeforeImputedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LeaseLiabilitiesImputedInterest" id="fenc_LeaseLiabilitiesImputedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RefundsDiscountsAndAllowances" id="fenc_RefundsDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InterestExpenseOnDebt" id="fenc_InterestExpenseOnDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InsurancePolicyFinanced" id="fenc_InsurancePolicyFinanced" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ThirdClosingNoteMember" id="fenc_ThirdClosingNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecuritiesPurchaseAgreementFirstAmendmentMember" id="fenc_SecuritiesPurchaseAgreementFirstAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="VariableInterestRateOverPrime" id="fenc_VariableInterestRateOverPrime" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtSecuritiesUnrealizedLoss" id="fenc_DebtSecuritiesUnrealizedLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NetLossForPeriod" id="fenc_NetLossForPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AdrianHaighMember" id="fenc_AdrianHaighMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementFundingReceived" id="fenc_LicenseAgreementFundingReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAgreementFundingPotentialMilestonePayments" id="fenc_LicenseAgreementFundingPotentialMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ExclusiveLicensingAgreementMember" id="fenc_ExclusiveLicensingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NorgineLtdMember" id="fenc_NorgineLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementsAbstract" id="fenc_LicenseAgreementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementDisclosureTextBlock" id="fenc_LicenseAgreementDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementPolicyPolicyTextBlock" id="fenc_LicenseAgreementPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PedmarkRevenue" id="fenc_PedmarkRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncrementalCostsCapitalizedToOtherNonCurrentAssets" id="fenc_IncrementalCostsCapitalizedToOtherNonCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncrementalCostsPaid" id="fenc_IncrementalCostsPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicensingRevenuePedmark" id="fenc_LicensingRevenuePedmark" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CostOfProductSales" id="fenc_CostOfProductSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ScheduleOfPedmarkRevenuesDiscountsAndAllowancesTableTextBlock" id="fenc_ScheduleOfPedmarkRevenuesDiscountsAndAllowancesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfPedmarkRevenuesNetTableTextBlock" id="fenc_ScheduleOfPedmarkRevenuesNetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CostToObtainContractPolicyTextBlock" id="fenc_CostToObtainContractPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PaymentOfPikInterest" id="fenc_PaymentOfPikInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AmortizationOfNorgineAsset" id="fenc_AmortizationOfNorgineAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DilutiveEffectOfRestrictedShareUnits" id="fenc_DilutiveEffectOfRestrictedShareUnits" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RestrictedShareUnitsToPurchaseCommonSharesMember" id="fenc_RestrictedShareUnitsToPurchaseCommonSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleDebtToPurchaseCommonSharesMember" id="fenc_ConvertibleDebtToPurchaseCommonSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
