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                          November 28, 2023

       Robert Andrade
       Chief Financial Officer
       Fennec Pharmaceuticals Inc.
       PO Box 13628, 68 TW Alexander Drive
       Research Triangle Park, NC 27709

                                                        Re: Fennec
Pharmaceuticals Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed November 9,
2023
                                                            File No. 333-275452

       Dear Robert Andrade:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Lauren
Hamill at 303-844-1008 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Garrett Sleichter