Fennec Pharmaceuticals Inc.
PO Box 13628, 68 TW Alexander Drive
Research Triangle Park, NC 27709


December 8, 2022

Via EDGAR Correspondence


Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F. Street, N.E.

Washington D. C. 20549


  Re: Acceleration of Effective Date
    Fennec Pharmaceuticals Inc.
    Registration Statement on Form S-3
    File No. 333-268632


Ladies and Gentlemen:


In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned respectfully requests that the effective date of the above-referenced Registration Statement be accelerated so that the same will become effective at 4:00 p.m., Eastern Time, on December 12, 2022, or as soon thereafter as is practicable.


  Very truly yours,
  By: /s/ Rostislav Raykov                  
    Rostislav Raykov
    Chief Executive Officer