United States securities and exchange commission logo

                           November 6, 2020

       Rostislav Raykov
       Chief Executive Officer, Director
       Fennec Pharmaceuticals Inc.
       PO Box 13628, 68 TW Alexander Drive
       Research Triangle Park, NC 27709

                                                        Re: Fennec
Pharmaceuticals Inc.
Statement on Form S-3
                                                            Filed October 30,
                                                            File No. 333-249775

       Dear Mr. Raykov:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jeffrey
Gabor at 202-551-2544 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Garett Sleichter, Esq.