United States securities and exchange commission logo November 6, 2020 Rostislav Raykov Chief Executive Officer, Director Fennec Pharmaceuticals Inc. PO Box 13628, 68 TW Alexander Drive Research Triangle Park, NC 27709 Re: Fennec Pharmaceuticals Inc. Registration Statement on Form S-3 Filed October 30, 2020 File No. 333-249775 Dear Mr. Raykov: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jeffrey Gabor at 202-551-2544 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Garett Sleichter, Esq.