SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Essetifin SPA (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol FENNEC PHARMACEUTICALS INC. [ FENC ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 12/12/2017
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	12/12/2017(1)		P		294,115(1)	A	$8.5	3,225,694	D(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* Essetifin SPA (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)

1. Name and Address of Reporting Person* CAVAZZA PAOLO (Last) (First) (Middle) VIA TESSERETE, 10 (Street) LUGANO V8 00000 (City) (State) (Zip)

1. Name and Address of Reporting Person* Cavazza Enrico (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)

1. Name and Address of Reporting Person* Cavazza Francesca (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)

1. Name and Address of Reporting Person* Cavazza Silvia (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)

1. Name and Address of Reporting Person* Cavazza Preta Martina (Last) (First) (Middle) VIA SUDAFRICA, 20 (Street) ROME L6 00144 (City) (State) (Zip)

Explanation of Responses:

1. Such shares were purchased in connection with a public offering by the issuer under a shelf registration statement, which closed on December 12, 2017.

2. Dispositive power over the shares of common stock owned by Essetifin S.p.A. is shared by Enrico Cavazza, Silvia Cavazza, Francesca Cavazza, Martina Cavazza Preta and Paolo Cavazza. Each of Enrico Cavazza, Silvia Cavazza, Francesca Cavazza, Martina Cavazza Preta and Paolo Cavazza disclaims beneficial ownership of all shares of common stock held by Essetifin S.p.A. except to the extent of any pecuniary interest therein.

	Essetifin S.p.A. By: /s/ Marino Zigrossi	12/14/2017
	/s/ Fabio Poma for Paolo Cavazza by power of attorney	12/14/2017
	/s/ Marino Zigrossi for Enrico Cavazza by power of attorney	12/14/2017
	/s/ Marino Zigrossi for Francesca Cavazza by power of attorney	12/14/2017
	/s/ Marino Zigrossi for Silvia Cavazza by power of attorney	12/14/2017
	/s/ Marino Zigrossi for Martina Cavazza Preta by power of attorney	12/14/2017
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

Exhibit 99.1

JOINT FILERS’ SIGNATURES

ESSETIFIN S.P.A.

By: /s/ Marino Zigrossi
Name: Marino Zigrossi
Title: Managing Director
Date: December 14, 2017
Enrico Cavazza
By: /s/ Marino Zigrossi
Name: Marino Zigrossi
Title: Attorney-in-fact
Date: December 14, 2017
Francesca Cavazza
By: /s/ Marino Zigrossi
Name: Marino Zigrossi
Title: Attorney-in-fact
Date: December 14, 2017
Silvia Cavazza
By: /s/ Marino Zigrossi
Name: Marino Zigrossi
Title: Attorney-in-fact
Date: December 14, 2017
Martina Cavazza Preta
By: /s/ Marino Zigrossi
Name: Marino Zigrossi
Title: Attorney-in-fact
Date: December 14, 2017
Paolo Cavazza
By: /s/ Fabio Poma
Name: Fabio Poma
Title: Attorney-in-fact
Date: December 14, 2017